Physics of chromatin maintenance
- Overview
- Single molecule studies to resolve the mechanics of SMC proteins
- Dynamics of DNA Supercoils
- Replication protein A (RPA) and HARP binding to DNA
- Chromatin Formation and Remodeling
- Homologous Recombination in Real Time
- High-speed AFM studies
- Live cell imaging of DNA repair processes
- Previous research topics
Using single-molecule imaging, nano-manipulation, and force-spectroscopy techniques we seek to unravel the mechanistic aspects of chromatin maintenance. Our research interests include (but are not limited to):
- Dynamic properties of nucleoprotein filaments
- Mechanistic aspects of strand exchange and strand invasion
- Homology search and homology recognition
- Chromatin remodeling