Bacterial Biophysics and bottom up biology


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Nanofabricated structures and bacterial growth therein

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks. With this approach, we assess the fundamental role of spatial confinement at the molecular, cellular and population level in biology. We use a bottom-up approach to recapture the main events occurring in cell division in vitro, working towards the aim to realize synthetic cell division.

Our current research focuses on:

1.  Biophysics of shape, scale, and intracellular patterns

2.  The mechanism of homology search during DNA repair

3.  Cooperation, competition, and antibiotic resistance in bacteria

4. Bottom-up approach to study Min proteins and DNA in nanochambers

5.  Synthetic cell division using liposomes on chip